1 MicroRNA - 21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension : Results of a Network Bioinformatics Approach Running title : Parikh et al . ; MiR - 21 controls pulmonary hypertension
نویسندگان
چکیده
1 Division of Cardiovascular Medicine and 3 Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women’s Hospital, Boston, MA; Center for Complex Network Research, Northeastern University, Boston, MA; Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute, Boston, MA; 5 Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, MA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA *These authors contributed equally to this work
منابع مشابه
MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach.
BACKGROUND Pulmonary hypertension (PH) is driven by diverse pathogenic etiologies. Owing to their pleiotropic actions, microRNA molecules are potential candidates for coordinated regulation of these disease stimuli. METHODS AND RESULTS Using a network biology approach, we identify microRNA associated with multiple pathogenic pathways central to PH. Specifically, microRNA-21 (miR-21) is predic...
متن کاملMolecular Cardiology MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension Results of a Network Bioinformatics Approach
Background—Pulmonary hypertension (PH) is driven by diverse pathogenic etiologies. Owing to their pleiotropic actions, microRNA molecules are potential candidates for coordinated regulation of these disease stimuli. Methods and Results—Using a network biology approach, we identify microRNA associated with multiple pathogenic pathways central to PH. Specifically, microRNA-21 (miR-21) is predicte...
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In this issue of Circulation, Parikh and colleagues1 present an elegant study that lies at the intersection of 2 recent major developments in cardiovascular research—the recognition of the role of microRNAs in normal and abnormal cardiovascular biology, and the introduction of computational systems biology approaches to elucidate the mechanisms of cardiovascular disease. This work provides conv...
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Pulmonary hypertension (PH) is a progressive and often fatal disorder whose pathogenesis involves pulmonary artery smooth muscle cell (PASMC) proliferation. Although modern PH therapies have significantly improved survival, continued progress rests on the discovery of novel therapies and molecular targets. MicroRNA (miR)-21 has emerged as an important non-coding RNA that contributes to PH patho...
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